TIPP

Nam-phuong Nguyen
The University of California at San Diego

Identifying species abundance from short fragmentary DNA sequences is a fundamental step in many metagenomic analyses. In this talk, we will present TIPP, a marker-based abundance profiling method that classifies metagenomic reads via phylogenetic placement. We will briefly describe the standard approach for phylogenetic placement, and then go into detail on how TIPP improves upon the standard approach. We will present a simulation study that shows TIPP has better abundance profiles than other recent profiling methods, and is robust even in the presence of high indel errors and novel genomes. Finally, we will describe future directions for TIPP, including developing a version of TIPP for virus identification.